Professional paper

Neuroendocrine carcinoma of the posterior mediastinum - a case report

Ana Krvavica ; Zadar General Hospital, Pathology and Forensic Medicine Department

Abstract

A tumor mass was noted in the posterior mediastinum on the tracheal bifurcation in a 64-year- old man.
Microscopically the tumor consisted of angiocentric atypical cylindrical epithelial cells that often form Flexner-Wintersteiner rosette and palisade. In the centre of the tumor island the cells were polygonal and showed bizzare multinucleated nuclei with marked necrosis and mitotic activity. The argentafillic bodies were identified by the Grimelius method. Immunohistochemically, the tumor cells expressed both epithelial and neuroendocrine markers, including Cytokeratin MNF-116, EMA, NSE, S-100, Synaptophysin and Chromogranin A; while CD-99, TTF-1, Vimentin, p-21 were negative. The described tumor was diagnosed as a rare, primary neuroendocrine carcinoma of large cells in the upper posterior med

Keywords

Neuroendocrine carcinoma; posterior mediastinum; tumor markers

Hrčak ID:

22835

URI

https://hrcak.srce.hr/22835

Publication date:

5.5.2008.

Article data in other languages: croatian

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