Original scientific paper

https://doi.org/10.20471/acc.2020.59.03.07

May Hemocytometer Parameters Be a Biomarker in Distinguishing between Adrenal Adenomas and Carcinomas and in Prognosis of Adrenocortical Carcinomas?

Pinar Sisman ; Medicana Hospital, Department of Endocrinology and Metabolism, Bursa, Turkey
Buket Bicer ; Uludag University Medical School, Department of Internal Medicine, Bursa, Turkey
Ozen oz Gul ; Uludag University Medical School, Department of Endocrinology and Metabolism, Bursa, Turkey
Soner Cander ; Uludag University Medical School, Department of Endocrinology and Metabolism, Bursa, Turkey
Canan Ersoy ; Uludag University Medical School, Department of Endocrinology and Metabolism, Bursa, Turkey
Ozlem Saraydaroglu ; Uludag University Medical School, Department of Pathology, Bursa, Turkey
Erdinc Erturk ; Uludag University Medical School, Department of Endocrinology and Metabolism, Bursa, Turkey

Abstract

Recently, studies have reported that inflammatory response and elevated platelet counts are associated with several cancers. In the present study, we aimed to evaluate hemocytometer parameters in differentiating adrenal adenoma and carcinoma, and the prognostic utility of hemocytometer parameters in adrenocortical carcinoma (ACC). We included 30 patients with nonfunctional adrenal adenoma and 13 patients with ACC having undergone surgery between 2005 and 2017 and followed up postoperatively at our centre. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), red blood cell distribution width (RDW), mean platelet volume (MPV) and plateletcrit (PCT) were evaluated preoperatively in all patients included in the study. There was a significant difference between the adrenal adenoma and ACC groups in terms of neutrophil and lymphocyte counts, NLR and PLR. There was no significant difference between the two groups in terms of platelet count and MPV, but PCT levels were significantly lower in ACC group. There was no statistically significant difference between recurrent and/or metastasis positive patients and negative ones according to NLR, PLR, RDW and MPV. There was a statistically significant difference in RDW levels and tumor diameter between the groups. Our study is the first to evaluate hemocytometer parameters in differentiating adrenal adenomas and carcinomas, and also in the prognosis of ACC. The present study suggested that the hemocytometer parameters may be a marker in the differential diagnosis of adrenal adenomas and carcinomas. However, our study also showed that these parameters had no prognostic value in ACC.

Keywords

Adrenal adenoma; Adrenocortical carcinoma; Hemocytometer parameters; Mean platelet volume; Neutrophil to lymphocyte ratio

Hrčak ID:

247389

URI

https://hrcak.srce.hr/247389

Publication date:

1.9.2020.

Article data in other languages: croatian

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