Acta clinica Croatica, Vol. 59. No. 3., 2020.
Other
https://doi.org/10.20471/acc.2020.59.03.20
Collecting Duct Carcinoma and Endemic Nephropathy – Case Reports and Literature Review
Matej Knežević
; Department of Urology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Karla Tomić
; Department of Pathology, Dr Josip Benčević General Hospital, Slavonski Brod, Croatia
Damir Dittrich
; Department of Urology, Dr Josip Benčević General Hospital, Slavonski Brod, Croatia
Ivana Vuković Lela
; School of Medicine, University of Zagreb, Zagreb, Croatia; Department of Nephrology, Arterial Hypertension and Dialysis, Zagreb University Hospital Centre, Zagreb, Croatia
Boris Ružić
; Department of Urology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Borislav Spajić
; Department of Urology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Krešimir Karlović
; Department of Urology, Dr Josip Benčević General Hospital, Slavonski Brod, Croatia
Goran Štimac
; Department of Urology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia;
Abstract
Although collecting duct carcinoma is a subtype of renal cell carcinoma, several studies implicate association with urothelial carcinoma. The coexistence of collecting duct carcinoma and another renal neoplasm is rare. Endemic nephropathy is a renal disease causing chronic renal
failure. It is highly associated with urothelial neoplasm and occurs in endemic villages in Bosnia, Croatia, Bulgaria, Romania and Serbia. Recent studies have confirmed the important role of exposure to aristolochic acid as an etiologic factor. We present three cases of collecting duct carcinoma with literature overview. In one case, we describe collecting duct carcinoma with metachronous urothelial carcinoma of the pyelon and urinary bladder in an endemic nephropathy patient. To our knowledge, this is the first case report describing this coexistence. Certain similarities between collecting duct carcinoma and urothelial carcinoma were found, e.g., higher incidence in female compared to male, higher mean age, and multifocal and multicentric occurrence of the tumor. Our observations support the hypothesis that collecting duct carcinoma and urothelial carcinoma could be connected.
Keywords
Collecting duct carcinoma; Bellini duct carcinoma; Endemic nephropathy; Kidney neoplasm; Renal failure; Urothelial carcinoma
Hrčak ID:
247643
URI
Publication date:
1.9.2020.
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