Short communication, Note

https://doi.org/10.2478/v10007-008-00011-6

2-Amino-5-sulfanyl-1,3,4-thidiazoles: A new series of selective cyclooxygenase-2 inhibitors

RAJESH SHARMA
JITENDRA SAINY
SUBHASH CHANDRA CHATURVEDI

Abstract

A new series of cyclooxygenase-2 inhibitors with 2-amino-5-sulfanyl-1,3,4-thiadiazole as the central scaffold unit has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for cyclooxygenase inhibitory activity by colorimetric COX (ovine) inhibitor screening assay, anti-inflammatory activity by the carrageenean induced rat paw oedema test and analgesic activity by the tail flick method. Some compounds exhibited significant biological activity.

Keywords

2-amino-5-sulfanyl-1,3,4-thiadiazoles, cyclooxygenase-1; cyclooxygenase-2; anti-inflammatory activity; analgesic activity

Hrčak ID:

22932

URI

https://hrcak.srce.hr/22932

Publication date:

1.9.2008.

Article data in other languages: croatian

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