Original scientific paper
Hyperferritinemia and COVID-19?
Ivana Čepelak
Slavica Dodig
Ivana Vučenik
Abstract
It has been repeatedly described that increased serum ferritin concentration or hyperferritinemia is as- sociated with COVID-19, especially with more severe forms of this disease.
Ferritin is a molecule whose concentration is determined as a marker of reflecting the body’s iron supply and less significantly as a marker of inflammation of infectious and non-infectious origin. The expression of this vital molecule for iron metabolism is therefore regulated, primarily by an iron- dependent mechanism. However, in addition to this regulation, there appears to be feedback between ferritin and cytokines in the control of pro-inflammatory and anti-inflammatory mediators.
This review paper includes basic data on ferritin and the potential causes and consequences of hyper- ferritinemia with implications for COVID-19.
Keywords
hyperferritinemia; COVID-19; inflammation; iron metabolism; ferritin
Hrčak ID:
248876
URI
Publication date:
15.12.2020.
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