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Note on the Preparation of Some Thiobarbiturates

D. Dvornik ; Research Department, »Pliva« Pharmaceutical and Chemical Works , Zagreb, Croatia, Yugoslavia
S. M. Djokić ; Research Department, »Pliva« Pharmaceutical and Chemical Works , Zagreb, Croatia, Yugoslavia

Abstract

It has been shown that barbituric acid derivatives can be prepared in good yield by gradually adding sodium methoxide as condensation catalyst to a cyanoacetic or malonic ester reacting with urea or its derivatives. The principle of the gradual addition of sodium methoxide as condensing agent has now been extended to condensations of some substituted cyanoacetic and malonic esters with thiourea.

Keywords

Hrčak ID:

249469

URI

https://hrcak.srce.hr/249469

Publication date:

31.7.1954.

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