Short communication, Note

Note on the Preparation of 5-Phenyl-oxazolidine-2,4-dione

D. Dvornik ; Research Department, »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia

Abstract

5- Phenyl-oxazolidine- 2,4 - dione has been prepared by the condensation of ethyl mandelate witth guanidine nitrate and subsequent hydrolysis of the 2- imino intermedlate by condensing »acetone-mandelic acid« or ethyl mandelate with urethane; by the condensation of ethyl mandelate with urea or 1- acetyl-3-methyl-urea; by the reaction of ethyl a-chloro-phenylacetate with urea or 1-acetyl- 3-methyl-urea and subsequent hydrolysis; by condensing mandelamide with diethyl carbonate. 5-Phenyl-oxazolidine-2,4-dione was furthermore obtained by the alkaline hydrolysis of 1,5 -diphenyl- and 1-methyl-5-phenyl- dialuric acid and 5-bromo-1,5-diphenyl and 5- bromo -1-methyl- 5-phenyl-barbituric acid with subsequent acid hydrolysis of the 2-imino-intermediates and, by the action of alkali on 1-(phenyl-chloroacetyl)-3-phenyl-urea and (phenyl-chloroacetyl)-urea.

Keywords

Hrčak ID:

249491

URI

https://hrcak.srce.hr/249491

Publication date:

31.1.1954.

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