Original scientific paper
Recoverability of reproductive system in patients with concomitant hyperandrogenism
Ravzat Abdulatipovna Saidova
; Department of Obstetrics and Gynaecology, Medical and Preventive Faculty, I.M. Sechenov First Moscow State Medical University of the Ministry of the Russian Federation
Abstract
Introduction. Adrenal hyperandrogenism (HA) exerts a negative effect on the women’s reproductive system (RS), while ovarian HA is preconditioned by the anovulation state. There are contradictory opinions on the infl uence of different androgens on the functions of women’s reproductive system. The main criteria of the assessment and importance of these factors remain undefined. Aim. In total, 105 women were examined and treated in the study, including a control group of women aged 19 to 37 (mean age 27,39±0,75), and patients with menstrual (opso- and oligomenorrhea) and reproductive (infertility and miscarriage) dysfunctions. Methods. The hormonal panel tests were also performed in the course of the menstrual cycle, on days 5–7 and 21–23, assessing the level of secretion of peptide and steroid sex hormones. Results. Combined HA is one of the leading pathogenic causes of menstrual and reproductive dysfunctions. Anovulation state causes an increase in the level of the main androgens, and the luteal phase deficiency is a consequence of the negative impact of HA. Individual pathogenesis-based therapy, allows recovering ovulation and securing pregnancy against a background of normalization of androgen metabolism and other indicators of the reproductive system functioning. Conclusion. The criteria for differential diagnostics of hyperandrogenic states and assessment of reproductive dysfunctions allows finding an individual treatment pattern.
Keywords
hyperandrogenism; anovulation; luteal phase defi ciency; polycystic ovary syndrome; testosterone; dihydrotestosterone; infertility
Hrčak ID:
251505
URI
Publication date:
1.12.2016.
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