Medicus, Vol. 16 No. 1_Dermatologija, 2007.
Review article
Topical Corticosteroids in Dermatovenerology - When, Why and What?
Jasna Lipozenčić
Biljana Gorgievska Sukarovska
Abstract
Topical corticosteroids play an important role
in dermatological therapy. Although they were introduced more
than half a century ago, they have remained a mainstay of
local dermatological therapy. These agents have anti-infl ammatory,
antiproliferative, immunosuppressive, and vasoconstrictive
action. According to their potency, topical corticosteroids are
classifi ed into either 4 groups (Europe) or 7 groups (USA). They
are available in a variety of vehicles, including ointments, creams,
lotions, gels, and foams. The vehicle used can signifi cantly
affect the corticosteroid action and potency. The absorption of
corticosteroids is different in different anatomic regions, and
it is related to the thickness of the stratum corneum, vascular
supply, or hairy areas. Patient age, as well as the type, extension
and site of the lesion, should be considered when choosing a
topical corticosteroid. Mild corticosteroids are reserved for the
face, inguinal and axillary regions, and for use in children and
the elderly. For other skin regions in adults, midstrength corticosteroids
are usually used, whereas potent agents are used for
thick chronic lichenifi ed plaques on the feet and hands. Prolonged
and irrational use of corticosteroids can be associated with
several side effects, both those on the site of application and
systemic side effects. Therefore recommendations on the use
of topical corticosteroids should be strictly followed. Intermittent
use of corticosteroids and combinational therapy with other
topical preparations are recommended to achieve maximal
effi cacy with minimal adverse effects.
Keywords
topical corticosteroids; topical therapy; adverse effects
Hrčak ID:
23277
URI
Publication date:
25.1.2007.
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