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Medicina Fluminensis, Vol. 43. No. 1, 2007.

Professional paper

ANTIMICROBIAL SUSCEPTIBILITY OF NASOPHARYNGEAL STREPTOCOCCUS PNEUMONIAE STRAINS TO BETA-LACTAMS

Brigita Tićac ; Institut of Public Health, Primorsko Goranska County, Rijeka, Croatia
Palmira Kesovija ; Institut of Public Health, Primorsko Goranska County, Rijeka, Croatia
Tomislav Rukavina ; Institut of Public Health, Primorsko Goranska County, Rijeka, Croatia

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Abstract

ABSTRACT
The asymptomatic nasopharyngeal carriage of Streptococcus pneumoniae (S. pneumoniae) is widely prevalent in children and has been related to the development of disease and the spread of the pathogen.The bacteria carried in the nasopharynx of healthy children reflect the infection-
causing strains currently circulating in the community, and so studies of the prevalence of different pathogens and their resistance patterns can provide useful indications for more rational therapeutic and preventive strategies1,2. Present studies have been focused mainly on the incidence of antibiotic-resistant pneumococci among out-patients. S. pneumoniae was isolated from 2464/33.139 (7.4%) specimens. From 01. 01. 2003. till 31. 12. 2006. the susceptibility
of 2464 Streptococcus pneumoniae strains to erythromycin, azithromycin, clindamycin, tetracycline, and trimethoprim-sulfamethoxazole was tested using the disk diffusion method. In (86) isolates with reduced sensitivity to penicillin (as determined with oxacillin disk method), minimal inhibitory concentrations (MIC) of penicillin and ceftriaxone was tested by the E-test (AB
Biodisk) method. Sensitivity to penicillin was found in 1971 (80%) of the 2464 Streptococcus pneumoniae while 493 (20%) of the isolates demonstrated decreased susceptibility. Isolates with
reduced sensitivity to penicillin had MICs from 0.125 to 1.5 μg/ml. 418 (18%) isolates were resistant to erythromycin, azithromycin and clarythromicin, 370 (16%) to clindamycin, 297 (11%) to tetracycline, and 543 (22%) to trimethoprim-sulfamethoxazole.

Keywords

Streptococcus pneumoniae; nasopharingeal carriage; beta-lactams; susceptibility

Hrčak ID:

23335

URI

https://hrcak.srce.hr/23335

Publication date:

20.3.2007.

Article data in other languages: croatian

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