Review article
https://doi.org/10.3325/cmj.2020.61.159
Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases
Miroslav Radman
; Mediterranean Institute for LifeSciences (MedILS), Meštrovićevo šetalište 45, Split, Croatia
Abstract
Health can be defined as a harmony, or homeostasis, of the
activities of thousands of different proteins, whereas aging
and diseases result from their disharmony manifested at
the levels of cells and tissues. Such disharmony is caused
primarily by dysfunction and toxicity of misfolded proteins
damaged by oxidation. This is an overview of key data that
inspired new concepts allowing interpretation and inte-
gration of the scientific literature on aging and age-related
diseases. These concepts suggest strategies for prevention
and attenuation of age-related degenerative and malig-
nant diseases mimicking the life of super-centenarians.
Keywords
Hrčak ID:
253164
URI
Publication date:
14.6.2020.
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