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Acta Pharmaceutica, Vol. 71 No. 4, 2021.

Short communication, Note

https://doi.org/10.2478/acph-2021-0044

Propolis – quality analysis and use in topical formulations

KRISTINA RAMANAUSKIENE ; Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukileliu Street 13, LT-50161 Kaunas, Lithuania
ASTA MARIJA INKENIENE orcid id orcid.org/0000-0002-1966-2237 ; Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukileliu Street 13, LT-50161 Kaunas, Lithuania
KRISTINA PERMINAITE ; Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukileliu Street 13, LT-50161 Kaunas, Lithuania
MODESTAS ZILIUS ; Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukileliu Street 13, LT-50161 Kaunas, Lithuania
DAIVA MAJIENE ; Neuroscience Institute, Lithuanian University of Health Sciences, Eivenių Street 4, Kaunas, Lithuania

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Abstract

The aim of this study was to produce propolis extracts, assess their quality and effect on skin cells and determine the penetration of active ingredients from designed semi-solid topical formulations. The use of higher-concentration ethanol and a larger amount of raw material allows extracting a larger quantity of active ingredients from raw propolis. In order to achieve effective extraction of compounds from raw materials, the use of ultrasound extraction is recommended for the production of aqueous extracts. Ultrasound extraction is an effective method for the production of aqueous extracts of propolis. The results show that depending on concentration, propolis extracts reduce the viability of keratinocytes. The phenolic compounds under observation penetrated the epidermis and dermis from designed formulations. The base of semi-solid formulation influences the efficacy of propolis preparations. The overall quantity of phenolic compounds that penetrated the skin was around 2 % from the ointment and 1.5 % from the cream.

Keywords

phenolic compounds; propolis extracts; skin penetration; cell viability

Hrčak ID:

253955

URI

https://hrcak.srce.hr/253955

Publication date:

31.12.2021.

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