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Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, Vol. 17 No. 1, 2008.

Original scientific paper

ABNORMAL GLUCOSE CHALLENGE TEST AND MILD GESTATIONAL DIABETES

Ayse Kafkasli ; Department of Obstetrics & Gynecology, Obstetrics & Gynecology Clinic of Inonu University Medical Faculty Malatya Turkiye
Ayse C. Sertkaya ; Departement of Internal Medicine, Division of Endocrinology of Inonu University Medical Faculty Malatya Turkiye
Engin B. Selcuk ; Departement of Family Medicine of Inonu University Medical Faculty Malatya Turkiye
Kezban Dogan ; Department of Obstetrics & Gynecology, Obstetrics & Gynecology Clinic of Inonu University Medical Faculty Malatya Turkiye
Feza Burak ; Obstetrics & Gynecology Clinic, Ozel Dogu Hospital, Malatya Turkiye
Saim Yologlu ; Department of Biomedical Statistics of Inonu University Medical Faculty Malatya Turkiye

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Abstract

Objective. The status of carbohydrate metabolism of pregnant women with positive glucose challenge test (GCT), but normal oral glucose tolerance test (OGTT) and their neonates are not defined clearly. Study Design. Pregnant women with normal GCT (n: 120), with abnormal glucose challenge test (AGCT) but normal OGTT (n: 67) and with gestational diabetes (GDM, n: 67) were included into the study. Insulin sensitivity was evaluated by fasting insulin level, homeostasis model assessment of insulin resistance index (HOMA-IR); quantitative insulin check index (QUICKI) and ISOGTT. Serum insulin and glucose values during OGTT were documented. Perinatal outcome and delivery modalities were compared. Results. Both GDM (31.6±5.9 yrs) and AGCT groups (29.0±4.0 yrs) were older than controls (28.1±4.9 yrs). Body mass index (BMI) was the predominant factor affecting both AGCT and GDM groups (OR: 3.78 and 5.97 respectively). Despite there was no significance between insulin indices; serum glucose and insulin values were similarly different; macrosomic infant and caesarean section rates were higher than controls in both GDM and AGCT groups in favor of gestational diabetics (6.6% vs. 18.9%; p=0.0001 and 20% vs. 27.7% p=0.0001 respectively). Conclusion. Pregnant woman with abnormal glucose challenge test have impaired carbohydrate metabolism as in gestational diabetics with a lesser severe degree.

Keywords

50 g glucose challenge test; glucose tolerance test; mild gestational diabetes; gestational diabetes; insulin levels; pregnancy

Hrčak ID:

23519

URI

https://hrcak.srce.hr/23519

Publication date:

1.3.2008.

Article data in other languages: croatian

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