Review article

INVASIVE DIAGNOSTIC PROCEDURES IN MULTIPLE PREGNANCIES

Aris J. Antsaklis ; 1st Department of Obstetrics and Gynaecology, »Alexandra« Maternity Hospital, University of Athens, Medical School, Athens, Greece
George A. Partsinevelos ; 1st Department of Obstetrics and Gynaecology, »Alexandra« Maternity Hospital, University of Athens, Medical School, Athens, Greece

Abstract

Over the past few years, the rising rate of multiple pregnancies, attributed to both increasing reliance on infertility treatment modalities and delayed childbearing, has expanded the need for prenatal invasive genetic testing. In multiples, first-trimester chorionic villus sampling and second-trimester amniocentesis are relatively safe and efficient alternative procedures, whereas fetal blood sampling is reserved for cases where an indefinite result of fetal karyotyping needs elucidation. The choice of invasive technique should be based on gestational age at referral date, procedure related risks and technical demands, but experience of the center performing the modality should be emphasized in decision making. Technological advances in modern high resolution ultrasound equipment along with increasing operator experience available today result in more accurate and efficacious invasive prenatal diagnosis in twin or higher-order pregnancies, minimizing potential post-procedural fetal loss rate.

Keywords

Genetic testing; multiple pregnancy; prenatal diagnosis

Hrčak ID:

23521

URI

https://hrcak.srce.hr/23521

Publication date:

1.3.2008.

Article data in other languages: croatian

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