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Acta Dermatovenerologica Croatica, Vol. 28 No. 4, 2020.

Original scientific paper

Contact Sensitivity in Patients with Atopic Dermatitis

Ružica Jurakić Tončić ; Department of Dermatology and Venereology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Suzana Ljubojević Hadžavdić orcid id orcid.org/0000-0002-3640-9567 ; Department of Dermatology and Venereology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Nives Pustišek ; Department of Dermatology, Children’s Hospital Zagreb, Zagreb, Croatia
Sandra Marinović Kulišić ; Department of Dermatology and Venereology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Alen Švigir ; Department of Pulmology, Allergology, Rheumatology and Clinical Immunology, Children’s Hospital Zagreb, Zagreb, Croatia

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Abstract

Atopic dermatitis (AD) is a common chronic and relaps-
ing, non-contagious inflammatory skin disorder, characterized by

skin barrier impairment and baseline immune irregularities. The

literature on the relationship between AD and cutaneous delayed-
type hypersensitivity is inconclusive. There is an ongoing debate

whether contact sensibility (CS) is found more or less often among
patients with AD. Aim of the study was to evaluate the incidence of
contact sensitivity (positive patch test reactions) in patients with and
without AD. We patch tested a total of 2143 patients (563 men and
1580 women). There were 226 patients with history of AD; 61 (27%)
men and 165 (73%) women. The patient group without AD consisted
of 1917 patients, 502 (26%) male and 1415 (74%) female patients,

who were referred to our Department with clinical suspicion of al-
lergic contact dermatitis (ACD). A patch test was performed with

the baseline series, and readings were performed on days D2, D3,
and D7. Among patients with AD, 109 (48.2%) had a positive patch
test reaction to at least one allergen, whereas 1094 (57.1%) patients
with no history of AD had a positive patch test reaction. The most
common positive allergens in patients with AD were nickel (II) sulfate

(13.3%), thimerosal (12.4%), cobalt (II) chloride (11.5%), methylisothi-
azolinone (MI) (8.4%), fragrance mix I (6.6%), potassium dichromate

(5.3%), methyldibromo glutaronitrile (4.0%), and carba mix (4.0%).
The results of our study agree with previous findings that there is
no significant difference in prevalence of CS between the atopic and
nonatopic populations.

Keywords

atopic dermatitis, contact sensitivity, patch test

Hrčak ID:

255057

URI

https://hrcak.srce.hr/255057

Publication date:

30.12.2020.

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