Review article

Comorbidities and Associated Risk in Migraine

Sanja Tomasović

Abstract

Migraine has many presumed comorbidities which have rarely been compared between samples with and without migraine. Examining the association between headache pain intensity and monthly headache day (MHD), frequency with migraine comorbidities is novel and adds to our understanding of migraine comorbidity. Chronic migraine is caused by chronification of the episodic migraine, i.e., by increasing the frequency of headache days to 15 and more per month. The following risk factors are predictors for the progression of an episodic migraine to a chronic form: increased frequency of headaches, excessive use of analgesics, cutaneous allodynia and obesity, as well as some comorbidities, including chronic pain syndromes outside the cephalic area, anxiety and depression. We can also mention cardiovascular, neurological, gastrointestinal and dermatological comorbidities. In regression models controlled for sociodemographic variables, all conditions studied were reported more often by those with migraine. Whether entered into the models separately or together, headache pain intensity and MHD frequency were associated with increased risk for many conditions. Future work is required (MAST Study) to understand the causal sequence of relationships (direct causality, reverse causality, shared underlying predisposition), the potential confounding role of healthcare professional consultation and treatment, and potential detection bias.

Keywords

chronic migraine; comorbidities; risk factors

Hrčak ID:

257513

URI

https://hrcak.srce.hr/257513

Publication date:

17.5.2021.

Article data in other languages: croatian

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