Professional paper

PLACENTAL ALKALINE PHOSPHATASE AS A BIOCHEMICAL MARKER OF IDIOPATHIC PRETERM DELIVERY

Gordana Grgić ; Department of Gynaecology and Obstetrics, University Clinical Centar and Medical School, Tuzla, Bosnia and Herzegovina
Zlatan Fatušić ; Department of Gynaecology and Obstetrics, University Clinical Centar and Medical School, Tuzla, Bosnia and Herzegovina
Nijaz Tihić ; Institute of Microbiology, University Clinical Centar and Medical School, Tuzla, Bosnia and Herzegovina
Lejla Begić ; Medical School University of Tuzla, Bosnia and Herzegovina
Gordana Bogdanović ; Department of Gynaecology and Obstetrics, University Clinical Centar and Medical School, Tuzla, Bosnia and Herzegovina
Fahrija Skokić ; Department of Gynaecology and Obstetrics, University Clinical Centar and Medical School, Tuzla, Bosnia and Herzegovina

Abstract

Different researches pointed out that human placental alkaline phosphatase (hPIAP) can be used as a possible marker of idiopathic premature labour. Objective. To examine reliability of hPIAP in mothers serum as a marker of premature labour among pregnant women who had no any of known risks for premature labour and to determine critical value of hPIAP in pregnancies which terminated as a premature labour; to establish the relation between hPIAP and ¬newborns of low birth weight. Material and methods. The research is done in a form of prospective study of 150 pregnant women, who have had no known risks factors for premature labour and who have had adequate antenatal care. The value of hPIAP in serum of all pregnant women were determined in period from 20 to 24 weeks of pregnancy. In further course of pregnancy was evaluated does the premature labour occur more frequently in those with increased values of hPIAP in relation to women who had normal values. As a critical for hPIAP was taken the value over two medians (>2M). Results. The number of premature labours was 17 (11.3%). Mean value of hPIAP in pregnant women who delivered prematurely was 1195, while in those who gave birth on time 632.16. The difference is statistically significant (p<0.0001). Value of hPIAP >2M had 29 (19.34%) of women who gave birth prematurely. Conclusion. hPIAP can be used as a reliable marker of idiopathic premature labour in pregnant women who have no risk factor for premature labour. hPIAP values which is related to development of premature labour is 990 mU/l.

Keywords

preterm labour; placental alkaline phosphatase

Hrčak ID:

23859

URI

https://hrcak.srce.hr/23859

Publication date:

1.9.2006.

Article data in other languages: croatian

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