Professional paper
https://doi.org/10.37797/ig.41.1.2
Clinical Manifestations of Bartonella henselae Infection Among Children: A Single Centre Study
Ivana Valenčak-Ignjatić
orcid.org/0000-0003-1523-1031
; University Hospital for Infectious Diseases «Dr. Fran Mihaljević», Zagreb, Croatia
Diana Didović
; University Hospital for Infectious Diseases «Dr. Fran Mihaljević», Zagreb, Croatia
Ante Šokota
orcid.org/0000-0002-1038-4787
; University Hospital for Infectious Diseases «Dr. Fran Mihaljević», Zagreb, Croatia
Laura Prtorić
; University Hospital for Infectious Diseases «Dr. Fran Mihaljević», Zagreb, Croatia
Vedran Stevanović
orcid.org/0000-0002-8456-6276
; University Hospital for Infectious Diseases «Dr. Fran Mihaljević», Zagreb, Croatia
Oktavija Đaković Rode
orcid.org/0000-0001-8023-4314
; University Hospital for Infectious Diseases «Dr. Fran Mihaljević», Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Marija Gužvinec
; University Hospital for Infectious Diseases «Dr. Fran Mihaljević», Zagreb, Croatia
Branko Miše
; University Hospital for Infectious Diseases «Dr. Fran Mihaljević», Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Abstract
Objectives: The aim of this study was to analyze clinical manifestations, epidemiology and laboratory parameters of B. henselae infection among children treated at the University Hospital for Infectious Diseases “Dr. Fran Mihaljević”, Zagreb from January 2014 until June 2019.
Materials and methods: We retrospectively analyzed the epidemiology, clinical and laboratory characteristics among children with positive indirect immunofluorescence assay for B. henselae IgM and IgG or positive B. henselae polymerase chain reaction from lymph node aspirate.
Results: A total of 104 patients, 47 (45,1%) female and 57 (54,8%) male were enrolled. The median age was 9,7 (range, 1,1 to 17,3 years). A history of cat contact was present in 101 (97,1%) children. Acute infection was serologically confirmed in 87 (83,6%), in 5 (4,8%) with PCR while both methods were positive in 12 (11,5%) patients. The presentation on B. henselae infection were regional lymphadenopathy, disseminated disease, encephalopathy and fever of unknown origin. Suppurative inflammation was the most common complication in patients with lymphadenopathy 12/92 (13%). Full recovery was the most frequent outcome (96,1%).
Conclusion: B. henselae infection among children is usually a mild disease presented as regional lymphadenopathy. Serology and polymerase chain reaction are useful tests for diagnosis. Treatment duration and choice of therapy depend on clinical manifestation and developed complications.
Keywords
cat scratch disease; Bartonella henselae; children; lymphadenopathy; abscess; fever; encephalopathy
Hrčak ID:
259101
URI
Publication date:
18.6.2021.
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