Original scientific paper

https://doi.org/10.5562/cca3775

Synthesis, Characterization and Biological Activity of Oxovanadium(IV) Complexes Containing α-Amino Acid Schiff Bases and 5,6-Dimethyl-1,10-phenanthroline Ligands

Md. Nur Amin Bitu ; Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh
Md. Saddam Hossain ; Department of Chemistry, Begum Rokeya University, Rangpur-5400, Bangladesh
Md. Ali Asraf ; Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh
Md. Faruk Hossen ; Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh
Md. Kudrat-E-Zahan orcid.org/0000-0001-8159-5293 ; Department of Chemistry, University of Rajshahi, Rajshahi-6205, Bangladesh

Abstract

Five oxovanadium(IV) complexes of the type [VO(L)(DPhen)], containing Schiff base derived from α-amino acid, [where L =
3-hydroxybenzaldehyde-α-alanine (hb-Ala), 3-hydroxybenzaldehyde-DL-phenylalanine (hb-Phe), 3-hydroxybenzaldehyde-leucine (hb-Leu),
3-hydroxybenzaldehyde-glycine (hb-Gly) and 3-hydroxybenzaldehyde-DL-methionine (hb-Met) & DPhen = 5,6-Dimethyl-1,10-phenanthroline] have been synthesized and characterized by some physicochemical properties, molar conductance, magnetic susceptibilities measurements, elemental analysis, UV-Visible, FT-IR and EIS-MS spectral studies. The molar conductance values evidenced the non-electrolytic nature of the complexes. The magnetic moment values of the complexes are in accordance with the d1 electronic configuration of the VIVO2+ moiety and indicates the paramagnetic behavior of the complexes. IR spectral data indicates the coordination of tridentate amino acid Schiff base ligands to the vanadyl (VO2+) ion through O, N, O-donor. ESI-MS spectral study confirmed the proposed structure of the complexes. All the analytical data suggested that all the complexes possess to have distorted octahedral geometry. The complexes were screened for their antibacterial activity against four human pathogenic bacteria; two Gram positive Escherichia coli & Pseudomonas aeruginosa and two Gram negative Staphylococcus aureus & Bacillus cereus with Kanamycin (K-30) standard. The result shows that all the complexes have moderate to strong potential antibacterial activity against all the pathogenic bacteria.

This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords

α-amino acids; Schiff base; 5,6-dimethyl-1,10-phenanthroline; oxovanadium(IV) complexes; antibacterial activity

Hrčak ID:

259368

URI

https://hrcak.srce.hr/259368

Publication date:

7.3.2021.

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