Original scientific paper

The Role of IL-2 and rheumatoid factor in recurrent spontaneous abortion

Hossein Hadinedoushan orcid.org/0000-0002-7102-3045 ; Immunology Department, Research and Clinical Centre for Infertility, Yazd, Iran
Abbas Aflatounian ; Gynecology and Obstetrics Department, Research and Clinical Centre for Infertility, Yazd, Iran
Morteza Anvari ; Anatomy Department, Research and Clinical Centre for Infertility, Yazd, Iran

Abstract

Objective: Recurrent spontaneous abortion (RSA), the repetition of three or more consecutive abortions, occurs in approximately 1-2% of reproductive-aged women. It has been postulated that a number of repeated pregnancy losses may be related to immune causes. The purpose of this study was to determine the role of Interleukin (IL)-2and Rheumatoid Factor (RF) in RSA.
Materials and methods: This case control study was carried out on two different groups. Group I consisted of fifty-six women with a history of three or more RSA and group II consisted of sixty-three healthy women who have had no abortion history, with at least one successful pregnancy. The sera were examined for the presence of IL-2 by ELISA method, and RF by latex agglutination test.
Results: Two out of 56 women in group I had IL-2 in serum. None of the women in group II had IL-2 in serum. Also, 53.5% of women in group I and 6% of women in group II were positive for RF in different titers. There were significant differences between groups I and II for RF (P = 0.002).
Conclusions: Serum IL-2 concentration does not affect pregnancy outcome, and the prevalence of RF in RSA women was higher than in normal controls. It is therefore recommended that the role of RF in pregnancy outcome should be investigated.

Keywords

IL-2; rheumatoid factor; recurrent spontaneous abortion

Hrčak ID:

24158

URI

https://hrcak.srce.hr/24158

Publication date:

5.6.2008.

Article data in other languages: croatian

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