Biochemia Medica, Vol. 18 No. 2, 2008.
Case report
A new case of transient hyperphosphatasemia in a 21 -month-old child with recurrent wheezing - case repor
Renata Zrinski-Topić
orcid.org/0000-0002-3740-7854
; Department of Clinical Laboratory Diagnosis, SrebrnjakChildren's Hospital, Reference Centerfor Clinical Allergology in Children of the Ministry of Health, Zagreb, Croatia
Miljenko Raos
; Department of Pulmonology and Allergology in Infants and Small Children, Srebrnjak Children's Hospital, Reference Center for Clinical Allergology in Children of the Ministry of Health, Zagreb, Croatia
Jadranka Demirović
; Laboratory of Medical Biochemistry, University Hospital for Tumors, Zagreb, Croatia
Jadranka Živčić
; Department of Clinical Laboratory Diagnosis, SrebrnjakChildren's Hospital, Reference Centerfor Clinical Allergology in Children of the Ministry of Health, Zagreb, Croatia
Ivana Čepelak
; Department of Medical Biochemistry and Hematology, School of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Rajka Petrinović
; Laboratory of Medical Biochemistry, University Hospital for Tumors, Zagreb, Croatia
Slavica Dodig
; Department of Clinical Laboratory Diagnosis, SrebrnjakChildren's Hospital, Reference Centerfor Clinical Allergology in Children of the Ministry of Health, Zagreb, Croatia
Abstract
Introduction: A case of transient hyperphosphatasemia in a 21-month-old boy diagnosed with recurrent wheezing during acute respiratory infection is described.
Materials and methods: Determination of alkaline phosphatase catalytic activity was performed by the recommended photometric method, and elec-trophoretic separation of alkaline phosphatase isoenzymes on agarose gel by serum processing with lectin.
Results: During hospital treatment, increased catalytic activity of alkaline phosphatase was recorded (4109 U/L on day 1 and 2156 U/L on day 6). On control examination on day 27 of hospital admission, the value decreased to 505 U/L. Electrophoretic separation of alkaline phosphatase isoenzymes demonstrated a band faster than the hepatic-osseous isoenzyme, a fast anodal form.
Conclusion: A marked increase in the alkaline phosphatase catalytic activity with typical electrophoretic isoenzyme pattern persisting for several weeks points to transient hyperphosphatasemia. Additional unnecessary diagnostic work-up can be obviated by timely recognition of the phenomenon.
Keywords
hyperphosphatasemia; alkalinephosphatase; isoenzymes; wheezing; infant
Hrčak ID:
24163
URI
Publication date:
5.6.2008.
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