Review article

LIVER TRANSPLANTATION AND ALLERGY: TRANSPLANT-ACQUIRED FOOD ALLERGY

Jadranka Pavičić Šarić orcid.org/0000-0003-4124-8056 ; Department of Anestesiology, Reanimatology and Intensive Care, University Hospital Merkur, Zagreb, Croatia
Jelena Zenko orcid.org/0000-0002-4678-2832 ; Department of Anestesiology, Reanimatology and Intensive Care, University Hospital Merkur, Zagreb, Croatia
Milenko Bevanda ; Department of Internal Medicine, University Hospital Mostar, Mostar, Bosnia and Herzegovina
Danijel Bevanda ; Department of Internal Medicine, University Hospital Mostar, Mostar, Bosnia and Herzegovina

Abstract

Transplant-acquired food allergy is a well known phenomenon especially linked to liver transplants. Risk factors lie both in transplant recipient and transplant donor - age of recipient and the maturity of immune regulatory mechanisms, family history of atopy in recipient, young age of the donor and atopic history in donor. The exact mechanism has not yet been established and there are many different explanations of this pathophysiologic process. Transplanted liver is a large and well perfused organ, rich in pluripotent hematopoietic stem cells and donor's IgE antibodies that can alter immunological response in the host. Some studies suggest that post-transplant immunosuppression with tacrolimus is linked to an increased occurrence of IgE-mediated sensitization and manifestation of allergic disease.
Research in the field of transplant-acquired food allergy is not important only for transplant patients and physicians involved but also for understanding the mechanism of food allergy development in general population and potentially reducing this global health concerning issue.

Keywords

food allergy; transplantation; transplant; acquired food allergy

Hrčak ID:

262702

URI

https://hrcak.srce.hr/262702

Publication date:

4.4.2019.

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