Conference paper
LATE LIFE DEPRESSION AND LATE ONSET DEPRESSION: ARE THE SAME CLINICAL AND PATHOPSYSIOLOGICAL PICTURE?
Apostolos Papazacharias
; Department of Neurological and Psychiatric Sciences, University “Aldo Moro”, Bari, Italy
Giancarlo Logroscino
; Department of Neurological and Psychiatric Sciences, University “Aldo Moro”, Bari, Italy
Maria Rosaria Barulli
; Department of Neurological and Psychiatric Sciences, University “Aldo Moro”, Bari, Italy
Marcello Nardini
; Department of Neurological and Psychiatric Sciences, University “Aldo Moro”, Bari, Italy
Abstract
Phenomenological differences between older patients with late- and early-onset depression may reflect differences in aetiology
and neuropathological processes involved in these two types of depression. Early- onset depression has been mainly correlated to a
family history of depression while late-onset depression has been principally correlated to vascular dysfunction. The same cortical
and sub-cortical areas are involved in both types of depression. However, lesions in these brain areas and cognitive impairment are
most pronounced in late-onset depression. Based on these observations we propose a common neuroanatomical substrate but
different pathophysiological processes implicated in these two types of depression.
Keywords
late-onset depression; early-onset depression; cognitive deficits
Hrčak ID:
262751
URI
Publication date:
14.9.2010.
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