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Psychiatria Danubina, Vol. 31 No. suppl 2, 2019.

Conference paper

HYPERPROLACTINEMIA - SIDE EFFECT OR PART OF THE ILLNESS

Sandra Vuk Pisk orcid id orcid.org/0000-0001-9690-1265 ; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia ;Faculty of Dental Medicine and Health, “Josip Juraj Strossmayer” University of Osijek, Osijek, Croatia
Katarina Matić ; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Natko Gereš ; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Ena Ivezić ; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia ;Faculty of Dental Medicine and Health, “Josip Juraj Strossmayer” University of Osijek, Osijek, Croatia
Nedjeljka Ruljančić ; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia
Igor Filipčić orcid id orcid.org/0000-0002-3283-8786 ; Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia ;Faculty of Dental Medicine and Health, “Josip Juraj Strossmayer” University of Osijek, Osijek, Croatia ;School of Medicine, University of Zagreb, Zagreb, Croatia

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Abstract

Background: Hyperprolactinemia is associated with side effect of antipsychotics in people suffering from psychotic disorders.
However, increased prolactin levels (mlU/L) were found in patients suffering from the first psychotic episode who were not receiving
antipsychotic therapy. The assumption of this study is that the abnormality in the level of prolactin is associated with the effect and
influence of the disease, not the therapy that is carried out.
Subjects and methods: Study involved 54 female patients hospitalized in Psychiatric hospital "Sveti Ivan", whose average age
was 33.9 years. All patients had been diagnosed with a psychotic disorder (according to MKB-10, F20-F29). 18 patients had their
first psychotic episode, while 36 patients had relapses of psychotic disorder. The methods used were: PANSS scale and measurement
of prolactin concentration (Immunoanalyzer ACCESS 2, CLIA method). Arithmetic mean, standard deviations, correlation coefficient,
Mann Whitney U test and the chi-squared test were used.
Results: 75.5% of patients had prolactin values above the reference values (min 121, max 4192 ml/L). In a sample of patients
with first psychotic episode, 77.8% had elevated prolactin levels, while among re-hospitalized patients, elevated levels had 74.2%.
Statistically significant results were obtained: patients with higher pronounced symptoms had higher prolactin values, especially
particles on PANSS: P1 (delusions), N4 (Apathy), G15 (preoccupation) and G16 (active avoidance).
Conclusion: Elevated prolactin in patients has been demonstrated regardless of antipsychotic therapy, therefore the question of
etiology of hyperprolactinemia in psychotic disorders is questionable. The association of hyperprolactinemia with the severity of the
clinical picture has also been demonstrated, higher prolactin values indicating a stronger clinical picture, which calls into question
the protective role of prolactin in psychotic disorders.

Keywords

antipsychotics; first psychotic episode; hyperprolactinemia; prolactin; psychotic disorders

Hrčak ID:

262776

URI

https://hrcak.srce.hr/262776

Publication date:

29.5.2019.

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