Medicus, Vol. 30 No. 2 Astma i KOPB, 2021.
Review article
What is Severe Asthma?
Marija Gomerčić Palčić
Abstract
Severe asthma is a subtype of “difficult-to-treat” asthma. It is asthma that is uncontrolled despite good adherence, appropriate inhaler technique and therapy with high dose inhaled corticosteroids-long-acting-beta2 agonist (ICS-LABA), or requires high dose ICS-LABA to remain controlled. Patients with severe asthma have significant difficulties in everyday living, lower physical activity and working productivity, as well as social distancing which can worsen asthma severity, mimic asthma symptoms and falsely aggravate the stage of the disease resulting in inadequate therapeutic modality and poor outcome. Wrong assessment of disease severity leads to insufficient or excessive use of anti-inflammatory drugs with the evolution of side effects. The availability of biologics leads to increased awareness of patients with severe asthma and its phenotyping, which is of great importance because these patients can initiate personalized therapy with good therapy response.
Keywords
severe asthma; phenotype; biomarkers; biologics
Hrčak ID:
264149
URI
Publication date:
18.10.2021.
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