Conference paper

CADASIL AND BIPOLAR AFFECTIVE DISORDER

Hong Kai Lim ; School of Clinical Medicine, University of Cambridge, Cambridge, UK
Zachary A. Millar ; School of Clinical Medicine, University of Cambridge, Cambridge, UK
Rashid Zaman ; Centre for Mental Health Research in Association with University of Cambridge (CMHR-CU), Cambridge, UK ; Hertfordshire Partnership University NHS Foundation Trust, UK ; Department of Psychiatry, University of Cambridge, Cambridge, UK

Abstract

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare monogenic
disorder caused by mutations in the NOTCH3 gene. The clinical features are primarily neurological, which include recurrent
transient ischaemic attacks, strokes, and migraines. However, psychiatric manifestations which mainly include mood disturbances
have also been reported in CADASIL. Manic symptoms and bipolar disorders are rarely documented in CADASIL and existing
reports generally lack detailed descriptions of the psychiatric evaluation.
We discuss a case of Bipolar Affective Disorder (BD) in a British woman with a family history of CADASIL.
This case provides insight into the diagnosis and management of BD as well as the possible underlying aetiologies that should be
considered. The similarities between BD and CADASIL in terms of imaging, genetic, and therapeutic aspects raise the possibility of
common dysfunctional pathways. BD in CADASIL may warrant greater consideration by both psychiatrists as well as nonpsychiatric
specialists and further studies are required to understand the pathological significance.

Keywords

CADASIL; Bipolar Affective Disorder; EUPD

Hrčak ID:

264179

URI

https://hrcak.srce.hr/264179

Publication date:

4.9.2019.

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