Short communication, Note
Vasodilatory Prostaglandins in Perinatal Hypoxic Brain Damage
Darinka Šumanović-Glamuzina
Filip Čulo
Melanie-Ivana Čulo
Paško Konjevoda
Tomica Božić
Adisa Robović
Ivana Vukšić
Željka Bilinovac
Zdravko Kuzman
Abstract
Prostaglandin (PGE2 and PGI2) synthesis was determined in the cerebrospinal fluid (CSF) and serum of 19 hypoxic
neonates at the age of 5–96 hours by using Enzyme Linked Immunosorbent Assay (ELISA) method. Control group consisted
of 8 children of the same age whose samples were taken due to initial suspicion of neonatal meningitis. The prostaglandin
concentrations in CSF were correlated with initial hypoxic-ischemic encephalopathy (HIE) stage and neurological
findings of patients at the age of 12 months. The values of PGE2 and PGI2 in the CSF of children with perinatal
hypoxia (PNH) were significantly higher than in the children from the control group. The values of PGI2 in serum were
significantly higher than in »CSF« of patients with PNH. Although average values of PGE2 and PGI2 in the liquor were
higher in children with advanced stage of HIE, the differences between different stages were not statistically significant.
We did not find any significant correlation between average concentrations of prostaglandins and neurological findings
of the 12-month-old children.
Keywords
prostaglandins (PG); perinatal hypoxia (PNH); hypoxic-ischemic encephalopathy (HIE); cerebrospinal fluid (CSF); neurological outcome
Hrčak ID:
24462
URI
Publication date:
13.5.2008.
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