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Psychiatria Danubina, Vol. 26 No. suppl 1, 2014.

Conference paper

MIXED STATES: A “NEW” NOSOGRAPHIC ENTITY

Norma Verdolini ; School of Specialization in Psychiatry, University of Perugia, Perugia, Italy
Mark Agius ; South Essex Partnership University Foundation Trust, Bedfordshire Centre for Mental Health Research in association with the University of Cambridge, Department of Psychiatry, University of Cambridge, UK
Roberto Quartesan ; Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Perugia, Italy
Sandro Elisei ; Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Perugia, Italy

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Abstract

Objective: Mixed states represent a controversial topic in the current psychiatry. The definitions and the diagnostic criteria have
changed over the past years. The new DSM-5 classification will have a substantial impact in several fields: epidemiology, diagnosis,
treatment, research, education, and regulations.
Methods: We reviewed the latest literature by using the key words “mixed states” and “agitated depression” on the PubMed.
Results: Although there is a great expectation about the validity of the new DSM-5 mixed states diagnosis, little is known about
its application on large population study but the formulation of less restrictive and more specific criteria for the diagnosis of mixed
states represent a starting point for future researches, mainly in consideration of the fact that previous classifications consider the
MS a superposition of manic and depressive symptoms, underestimating the clinical complexity and the wider phenomenologic
variability of these conditions.
Conclusions: Clinical trials need to address treatment effects according to the presence or absence of mixed features in
consideration of the fact that replacing in the bipolar spectrum patients that traditionally are considered to be affected by unipolar
depression, represent a topical research hypothesis and has a practical remarkable importance in the appropriate therapeutic choice.

Keywords

mixed states; agitated depression; mood disorders; DSM-5

Hrčak ID:

265692

URI

https://hrcak.srce.hr/265692

Publication date:

5.11.2014.

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