Original scientific paper

West Syndrome with Periventricular Leukomalacia: Ten-year Clinical Study

Radenka Kuzmanić-Šamija
Biserka Rešić
Maja Tomasović
Dragana Gabrić Pandurić
Bernarda Lozić
Marin Lozić
Jasminka Rešić

Abstract

The aim of the study was to evaluate magnetic resonance imaging (MRI) findings in infants with periventricular
leukomalacia (PVL) andWest syndrome (WS) and determine the neurodevelopmental outcome in children withWest syndrome
and PVL. Ultrasound and brain MRI were performed in 37 infants with recognized PVL. PVL was categorized according
to De Vries, whereas West syndrome was categorized according to International League Against Epilepsy 1989.
West syndrome in our patients developed during the first 2 years of life. The most common interictal abnormality was
hypsarrhythmia. All, except two patients had delayed development and various degrees of mental retardation.The most
characteristic neuroimaging findings were major reduction in cerebral cortical gray matter volume, reduction in the volume
of brain myelin, and delayed myelination. These findings may explain the anatomical association between the West
syndrome onset and PVL and intellectual and cognitive deficit in premature infants with PVL.

Keywords

newborns; West syndrome; periventricular leukomalacia; MRI

Hrčak ID:

24562

URI

https://hrcak.srce.hr/24562

Publication date:

13.5.2008.

Visits: 2.956 *