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Psychiatria Danubina, Vol. 33 No. suppl 11, 2021.

Conference paper

EUROTROPISM AND NEUROPSYCHIATRIC SYMPTOMS IN PATIENTS WITH COVID-19

Patrizia Moretti ; Department of Psychiatry, University of Perugia, Perugia, Italy
Francesca Brufani
Valentina Pierotti
Giorgio Pomili
Agata Di Buo
Cecilia Giulietti
Filippo Masini
Vivjana Tanku
Massimo Claudio Bachetti
Giulia Menculini
Alfonso Tortorella

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Abstract

Background: The Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the Severe Acute Respiratory
Syndrome-CoronaVirus-2 (SARS-CoV-2). Beyond the most common clinical features of COVID-19, mainly represented by
respiratory symptoms, other systems may be interested by the infection. Among these, through a neurotropic pathway, the central
nervous system (CNS) may be affected by the virus, leading to developing neuropsychiatric symptoms. Particularly, this study
focuses on neurological symptoms determined by the Sars-CoV-2 infection, as well as on the underlying pathogenetic processes.
Methods: For the present review, we followed a narrative approach. A literature search was carried out concerning the
neurological consequences of COVID-19. Papers were screened, focusing on the clinical manifestations interesting the CNS and on
their possible role in the early diagnosis of the disease.
Results: We display the most significant neurological clinical manifestations of COVID-19. Common neurological manifestations
(ageusia, anosmia, and encephalitis) are first described. Subsequently, we provide a focus on delirium and its possible pathoge netic
and clinical correlates. Delirium is not only a possible resultant of the COVID-19 neurotropism, but it may also be precipitated by a
number of environmental factors that assume further relevance during the pandemic.
Conclusions: Neuropsychiatric symptoms, and particularly delirium, can help identifying the infection at an early stage. Tailored
treatments should be identified in order to prevent complications.

Keywords

neurotropism; delirium; SARS-CoV-2; COVID-19

Hrčak ID:

270200

URI

https://hrcak.srce.hr/270200

Publication date:

4.12.2021.

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