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Acta clinica Croatica, Vol. 60. No. 3., 2021.

Original scientific paper

https://doi.org/10.20471/acc.2021.60.03.07

Nomogram Containing Simple Routine Clinical and Biochemical Parameters Can Predict Pathologic Ventricular Remodeling in STEMI Patients

Ozren Vinter orcid id orcid.org/0000-0002-4236-7594 ; Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Krešimir Kordić orcid id orcid.org/0000-0002-9707-6946 ; Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Iva Klobučar ; Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Ivo Darko Gabrić orcid id orcid.org/0000-0003-4719-4634 ; Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Marko Boban orcid id orcid.org/0000-0002-6129-575X ; Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Matias Trbušić ; Sestre milosrdnice University Hospital Centre, Zagreb, Croatia

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Abstract

Heart failure is the leading cause of morbidity and mortality worldwide, with
ischemic heart disease being one of the most important etiologic factors. Heart failure develops due to
ventricular remodeling, which leads to increases in left ventricular end-systolic and end-diastolic volumes.
In this prospective observational study, we included 101 patients with first episode of ST-segment
elevation myocardial infarction in whom percutaneous coronary intervention was conducted
within 12 h and Thrombolysis in Myocardial Infarction III flow was achieved. The aim was to determine
which clinical and biochemical parameters can help predict pathologic ventricular remodeling
1 year after myocardial infarction. We created a nomogram based on routinely used blood tests and
vital parameters which showed highest correlation with pathologic ventricular remodeling. The nomogram
included NTproBNP value 12 h after reperfusion, aspartate transaminase value 12 h after reperfusion,
systolic blood pressure value on admission, and culprit coronary artery. We performed ROC
analysis which yielded great predictive value of the nomogram. The area under curve was 0.907 (95%
CI 0.842-0.973). The nomogram value of -3.54 had 91.4% sensitivity and 74.0% specificity. We believe
that this nomogram, once validated, could offer a widely available, low-cost option that would
help identify patients at risk of developing pathologic left ventricular remodeling and achieve this at a
very early stage of myocardial infarction (12 h after reperfusion has been achieved).

Keywords

Acute myocardial infarction; Left ventricular remodeling; End-diastolic volume; End-systolic volume

Hrčak ID:

271346

URI

https://hrcak.srce.hr/271346

Publication date:

1.9.2021.

Article data in other languages: croatian

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