Conference paper
PATHOPHYSIOLOGICAL BODY REACTIVITY AND INTERACTIONS IN COMORBIDITIES Synergism Versus Antagonism of Disease Pathways and Etiopathogenetic Clusters in Comorbidity Conditions
Zdenko Kovač
; Department of Pathophysiology, Medical School University of Zagreb, University Hospital Centre Zagreb, Zagreb, Croatia
Abstract
Complexity, variability, nonlinearity and adaptive alterations in human health and disease are considered within the integral
body physiology. Sokolić's principles and Koshland's pillars of life are referred as a conceptual frameworks for the whole-body
performance. Disease pathways and etiopathogenetic clusters (EPCs) form networks. Due to EPCs, pathways and networks body
reactivity gets reduced, and may lead to latent insufficiencies, a decompensation and death. Networking can be triggered by various
etiologies. Overlapping of one disease network with the other simultaneous ones may lead to interferences of a disease development and
manifestations. Comorbidity effects may be synergistic, and thus it leads to a more severe disease state. On the other side, antagonistic
interaction of the two diseases may lead to improvement and/or prevention. 20 comorbidities of each type are outlined in this paper.
Keywords
etiopathogenetic clusters (EPC); Sokolić's principles; Koshland's pillars; reactivity; comorbidity; synergism; antagonisms
Hrčak ID:
271687
URI
Publication date:
19.10.2021.
Visits: 321 *