Original scientific paper

https://doi.org/10.2478/v10007-008-0014-3

Liposomi rivastigmina za isporuku u mozak intranazalnim putem

KARTHIK ARUMUGAM ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
GANESA SUNDARARAJAN SUBRAMANIAN ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
SURULIVEL RAJAN MALLAYASAMY ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
RANJITH KUMAR AVERINENI ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
MEKA SREENIVASA REDDY ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India
NAYANABHIRAMA UDUPA ; Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka-576 104, India

Abstract

Glavni cilj rada je razvoj liposoma za intranazalnu primjenu za isporuku lijeka u mozak. U tu svrhu izabran je rivastigmin kao modelni lijek koji se upotrebljava u terapiji Alzheimerove bolesti. Liposomi su pripravljeni metodom hidratacije lipidnog sloja koristeći kolesterol i lecitin iz soje kao lipidne komponente. Praćena je koncentracija rivastigmina u mozgu i plazmi nakon intranazalne i peroralne primjene liposoma i slobodnog lijeka. S intranazalnim liposomima rivastigmina postignuta je značajno veća koncentracija lijeka u mozgu. Osim toga intranazalni liposomi imaju dulje vrijeme poluživota u mozgu. Intranazalna primjena liposoma rivastigmina mogla bi predstavljati novi pristup terapiji Alzheimerove bolesti.

Keywords

rivastigmin; liposomi; intranazalna primjena; isporuka lijeka u mozak; farmakokinetika

Hrčak ID:

25019

URI

https://hrcak.srce.hr/25019

Publication date:

1.9.2008.

Article data in other languages: english

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