Original scientific paper
https://doi.org/10.5599/jese.1101
Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3modified screen-printed graphite electrode
Fatemeh Irannezhad
; Department of Physics, Faculty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran
Jamileh Seyed-Yazdi
; Department of Physics, Faculty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran
Seyedeh Hoda Hekmatara
; Department of Physics, Faculty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran
Abstract
Asensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O//Fe2O3nanocomposite for 6-mercaptopurine detection based on a facile fabrication method. The surface morphology and structural composition of this nanocomposite wereevaluated by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), andFourier transform infrared (FT-IR) spectroscopy. The screen-printed graphite electrode (SPGE) modi-fied with RGO-Cu2O/Fe2O3nanocomposite (RGO-Cu2O/Fe2O3/SPGE) indicated excellent elec-trochemical properties to detect 6-mercaptopurine. The linear dynamic range was estimated between 0.05 and 400.0 μM for 6-mercaptopurine detection, with a limit of detection of 0.03 μM.Also, RGO-Cu2O/Fe2O3/SPGE sensor showed good activity for simultaneous detection of 6-mercaptopurine and 6-thioguanine. In the coexistence system of 6-mercaptopurine and 6-thioguanine, two clear and well-isolated voltammetricpeaks were obtained by differential pulse voltammetry (DPV). Additionally, the proposed sensor was examined for applicability by determining6-mercaptopurine and 6-thioguanine in real samples, and the recovery in the range of 97.5-103.0 % was obtained.
Keywords
electrochemical sensor; reduced graphene oxide; copper(I) oxide; iron(III) oxide
Hrčak ID:
273044
URI
Publication date:
24.2.2022.
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