Original scientific paper
https://doi.org/10.5599/jese.1117
Construction of a simple and selective electrochemical sensor based on Nafion/TiO2for the voltammetric determination of olopatadine
Mohammad Mehmandoust
; Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey
Amirhossein Mehmandoust
; Department of Chemistry, Faculty of Science, Urmia University, 1177, Urmia, Iran
Nevin Erk
; Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey
Abstract
A selective and facile voltammetric method based on titanium dioxide nanoparticles and Nafion (Nafion/TiO2NPs) on the screen-printed electrode (SPE) was proposed forolopatadinedetermination. Followed by the synthesis of TiO2nanoparticles, various methods, including high-resolution transmission electron microscopy (HR-TEM), ultraviolet-visible spectroscopy (UV-Vis),energy-dispersive X-ray (EDX) Raman spectrum, and electrochemical impedance spectroscopy (EIS) wereutilized tocharacterize the nanomaterials. Nafion/TiO2on the screen-printed electrode (NFN/TiO2/SPE) was used to determine olopatadine in concentration ranges of 0.01 to 0.07 and 0.07 to 14.6 μM with a limit of quantification as low as 7.0 nM, via differential pulse voltammetry technique. The NFN/TiO2/SPE offered a high-performance ability to determine olopatadine in the eye drop sample with satisfactory recovery data of 98.2–99.0 %. Also, the developed electrode showed good reproducibility, repeatability, and high selectivity features. The obtained results indicate that NFN/TiO2/SPE could be utilized as an appropriate candidate for electrochemical olopatadine sensing.
Keywords
Monitoring; screen-printed electrode, differential pulse voltammetry
Hrčak ID:
273048
URI
Publication date:
24.2.2022.
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