Original scientific paper

Protein C activity in babesiosis of dogs

Renata Barić Rafaj ; Clinic of Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Vladimir Mrljak ; Clinic of Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Nada Kučer ; Clinic of Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Mirna Brkljačić ; Clinic of Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Vesna Matijatko ; Clinic of Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia

Abstract

One of the numerous complications which could occur in babesiosis of dogs is disturbance in the coagulation system. The protein C pathway is one of the three major anticoagulant mechanisms and its activity was investigated in dogs with babesiosis, before and after therapy. We determined the decrease of protein C activity, which could be the consequence of inflammatory cytokines releasing, reduced synthesis in the liver, or increased erythropoietin production. Decrease in number of red blood cells and haematocrit could be due to mechanical, immuno-mediated or toxic-mediated haemolysis. Activity of aspartate-aminotransferase and alanine-aminotransferase and total bilirubin concentration was increased, indicating cellular damage of the liver.

Keywords

protein C; coagulation; babesiosis; dog

Hrčak ID:

25173

URI

https://hrcak.srce.hr/25173

Publication date:

20.2.2007.

Article data in other languages: croatian

Visits: 2.005 *