Original scientific paper

Anthelmintic activity of the crude methanol extract of Xylopia aethiopica against Nippostrongylus brasiliensis in rats

Mohammed Musa Suleiman ; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Mohammed Mamman ; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Yusuf Otaru Aliu ; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Joseph Ologunja Ajanusi ; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria

Abstract

Xylopia aethiopica A. Rich (X. aethiopica; Annonaceae) is used commonly in Nigeria by traditional herbalists and pastoralists to control gastrointestinal helminth parasites. The anthelmintic effect of the crude methanol extract was evaluated in rats experimentally infected with the rat hookworm Nippostrongylus brasiliensis. Thirtyfive rats were each infected subcutaneously with 200 third stage infective larvae of the parasite and randomly
grouped into seven groups. Five days after infection, rats in siof the groups were treated with the extract, the dose varying per group. Rats in the seventh (control) group were each given propylene glycol. Anthelmintic activity was assessed by comparing the number of worms recovered from treated rats to those from non-treated infected control rats. The extract at the dose of 0.8 g/kg, 1.0 g/kg, 1.2 g/kg, 1.4 g/kg, 1.7 g/kg and 2.0 g/kg produced deparasitization rates of 21%, 47%, 51%, 50%, 63% and 76% and were signifi cant (P>0.05) when compared to untreated control rats.

Keywords

Xylopia aethiopica; Nippostrongylus brasiliensis; anthelmintic; medicinal plant

Hrčak ID:

25201

URI

https://hrcak.srce.hr/25201

Publication date:

20.12.2005.

Article data in other languages: croatian

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