Original scientific paper
Immunohistochemical Expression of Matrix Metalloproteinase-1 and Cyclooxygenase-2 in Cutaneous Squamous Cell and Basal Cell Carcinoma
Sanda Smuđ Orehovec
orcid.org/0000-0003-4878-4417
; Division of Plastic and Reconstructive Surgery and Breast Surgery, Department of Surgery, University Hospital Centre Zagreb, Zagreb, Croatia
Anto Dujmović
; Division of Plastic and Reconstructive Surgery and Breast Surgery, Department of Surgery, University Hospital Centre Zagreb, Zagreb, Croatia
Davor Mijatović
; Division of Plastic and Reconstructive Surgery and Breast Surgery, Department of Surgery, University Hospital Centre Zagreb, Zagreb, Croatia
Marko Mance
; Division of Plastic and Reconstructive Surgery and Breast Surgery, Department of Surgery, University Hospital Centre Zagreb, Zagreb, Croatia
Božena Šarčević
; 2Division of Oncological Pathology and Clinical Cytology, Department of Clinical Pathology and Cytology “Ljudevit Jurak”, University Hospital for Tumors, University Hospital Center Sisters of Charity, Zagreb, Croatia
Abstract
The most common nonmelanoma skin cancers (NMSC) are basal
cell carcinoma (BCC) and squamous cell carcinoma (SCC). The incidence of
NMSC is 18-20 times higher than the incidence of melanoma. The Cyclooxygenase-
2 (COX-2) and Matrix Metalloproteinase-1 (MMP-1) enzymes have
both been linked to the development of these diseases but their exact significance
is unknown. We conducted a retrospective analysis on 148 adult
patients with cutaneous BCC and SCC. Cases were divided according to the
sub-types of BCC and the degree of SCC differentiation. Immunohistochemical
staining for COX-2 and MMP-1 was performed and analyzed to determine
if the expression of these biomarkers were associated with BCC subtypes and
the degree of SCC. differentiation.
We did not find a significant association of the level of differentiation of SCC
with the immunohistochemical expression for MMP-1 or COX-2. There was
a significant association between BCC subtypes and immunohistochemical
expression for MMP-1; positive expression of this enzyme reduces the odds
for the infiltrative subtypes by 90%. A marginally significant association between
BCC subtypes and immunohistochemical expression for COX-2 was
also found. This enzyme was highly expressed in non-infiltrative basal cell
carcinoma types (94%) compared with infiltrative types (71%). In conclusion,
we did not find a significant predictor for SCC expression levels for either of
two biomarkers, while the expression of MMP-1 in BCC was significantly inversely
associated with the infiltrative type (moderate sensitivity and high
specificity). Further research with larger sample sizes is needed to precisely
determine the role these enzymes have in these diseases.
Keywords
Hrčak ID:
274438
URI
Publication date:
17.3.2021.
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