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Archives of Industrial Hygiene and Toxicology, Vol. 73 No. 1, 2022.

Original scientific paper

https://doi.org/10.2478/aiht-2022-73-3605

Ochratoxin A potentiates citrinin accumulation in kidney and liver of rats

Dubravka Rašić orcid id orcid.org/0000-0002-0677-9305 ; Institute for Medical Research and Occupational Health, Toxicology Unit, Zagreb, Croatia
Srđan Stefanović orcid id orcid.org/0000-0002-8011-5654 ; Institute of Meat Hygiene and Technology, Department for Residues, Belgrade, Serbia
Dragan Milićević orcid id orcid.org/0000-0001-9001-0584 ; Institute of Meat Hygiene and Technology, Department for Residues, Belgrade, Serbia
Marin Mladinić ; 3 Institute for Medical Research and Occupational Health, Mutagenesis Unit, Zagreb, Croatia 4 LEO Pharma, Preclinical Development, Ballerup, Denmark
Davor Želježić orcid id orcid.org/0000-0002-8214-0212 ; Institute for Medical Research and Occupational Health, Mutagenesis Unit, Zagreb, Croatia
Alica Pizent orcid id orcid.org/0000-0003-0216-0166 ; Institute for Medical Research and Occupational Health, Analytical Toxicology and Mineral Metabolism Unit, Zagreb, Croatia
Paško Konjevoda ; Ruđer Bošković Institute, Division of Molecular Medicine, Laboratory for Epigenomics, Zagreb, Croatia
Maja Peraica ; Institute for Medical Research and Occupational Health, Toxicology Unit, Zagreb, Croatia

Full text: english pdf 367 Kb

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Full text: croatian pdf 367 Kb

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Abstract

Ochratoxin A (OTA) and citrinin (CTN) are nephrotoxic mycotoxins often found together in grain. The aim of this study was to measure their accumulation in the kidney and liver of adult male Wistar rats, see how it would be affected by combined treatment, and to determine if resveratrol (RSV) would decrease their levels in these organs. The rats received 125 or 250 mg/kg bw of OTA by gavage every day for 21 days and/or 20 mg/kg bw of CTN a day for two days. Two groups of rats treated with OTA+CTN were also receiving 20 mg/kg bw of RSV a day for 21 days. In animals receiving OTA alone, its accumulation in both organs was dose-dependent. OTA+CTN treatment resulted in lower OTA but higher CTN accumulation in both organs at both OTA doses. RSV treatment increased OTA levels in the kidney and liver and decreased CTN levels in the kidney. Our findings point to the competition between CTN and OTA for organic anion transporters 1 and 3.

Keywords

experimental rats; mycotoxins; organic anion transporters; resveratrol; toxicity

Hrčak ID:

274564

URI

https://hrcak.srce.hr/274564

Publication date:

30.3.2022.

Article data in other languages: croatian

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