Original scientific paper

https://doi.org/10.17559/TV-20210623123037

Development of Crystallization Calibration Model for Real-Time Monitoring of Fosamprenavir Calcium Particle Size Distribution

Hrvoje Dorić ; University of Zagreb, Faculty of Chemical Engineering and Techology, Marulićev trg 19, 10 000 Zagreb, Croatia
Nenad Bolf ; University of Zagreb, Faculty of Chemical Engineering and Techology, Marulićev trg 19, 10 000 Zagreb, Croatia
Damir Šahnić ; PLIVA Croatia Ltd. (member of TEVA group), Prilaz baruna Filipovića 25, 10000 Zagreb, Croatia

Abstract

New approach in development of a calibration model for continuous monitoring of particle size distribution during crystallization of Fosamprenavir Calcium in a laboratory scale set-up is presented. Calibration models were developed based on data generated from Fosamprenavir Calcium crystallization experiments. The applicability of the method for continuous monitoring was explored comparing particle size distributions calculated from the developed model and particle size distributions determined by the laser light scattering method. Based on the calibration model of the particular process, partial least squares regression algorithm for continuous monitoring of particle size distribution was derived and applied and the results were validated. Presented method finds its application for real-time monitoring of particle size distribution, based on chord length distribution measurements.

Keywords

calibration model; crystallization; partial least squares regression; particle size distribution; real-time monitoring

Hrčak ID:

275283

URI

https://hrcak.srce.hr/275283

Publication date:

19.4.2022.

Visits: 1.038 *