Original scientific paper

https://doi.org/10.57140/mj.52.1.1

Prognostic significance inflammatory scoring systems in critically ill patients with COVID-19 infection

Damir Mihić orcid.org/0000-0001-7999-6901 ; University Hospital Osijek, Department of pulmology and intensive medicine; University "Josip Juraj Strossmayer", Faculty of medicine Osijek
Lana Maričić orcid.org/0000-0001-6035-6760 ; University Hospital Osijek, Department of cardiology; University "Josip Juraj Strossmayer, Faculty of medicine Osijek
Ivana Tolj ; University Hospital Osijek, Department of nephrology; University "Josip Juraj Strossmayer, Faculty of medicine Osijek
Domagoj Loinjak orcid.org/0000-0002-7535-6744 ; University Hospital Osijek, Department of pulmology and intensive medicine; University "Josip Juraj Strossmayer", Faculty of medicine Osijek
Livija Sušić ; University "Josip Juraj Strossmayer", Faculty of medicine Osijek; Health Centre Osijek, Osijek
Ivana Begić ; University "Josip Juraj Strossmayer", Faculty of medicine Osijek

Abstract

Aim: The outbreak of novel coronavirus pneumonia that was first detected in Wuhan in December 2019
resulted in a worldwide pandemic. Approximately 25% of confirmed cases developed a severe disease and
the need for intensive care unit admission. The aim of this study was to determine the role of three
inflammatory scoring systems, C-reactive protein/albumin ratio, fibrinogen/albumin ratio, C-reactive
protein/lymphocyte ratio and their association with survival, comorbidities, and the occurrence of additional
complications in the intensive care of these patients.
Materials and methods: This retrospective study was conducted based on data collected by the Department
of Respiratory Center. Ethical approval for the study was obtained from the Ethics Committee of Osijek
University Hospital. This study analysed data retrospectively between October and December 2020, and
included 137 critically ill patients with a diagnosis of COVID-19.
Results: Data analysis of three examined inflammatory points of the system, below and above the median
found a significant association in the group below the median C-reactive protein/albumin ratio with the
presence of complications (p= 0,039) in the group above the median in the study of fibrinogen/albumin ratio
found a significant association with sepsis (p=0,043). In the group of participants who were above its median
in terms of C-reactive protein/lymphocyte ratio, there were more of those with the development of acute
kidney injury (p=0,014), and sepsis (p=0,009).
Conclusion: Inflammatory scoring systems, C-reactive protein/albumin ratio, fibrinogen/albumin ratio and
C‐reactive protein/lymphocyte ratio represent an independent prognostic indicator of the clinical course in
critically ill patients with COVID-19 infection.

Keywords

COVID-19; critically ill; C-reactive protein/albumin ratio; fibrinogen/albumin ratio; C-reactive protein/lymphocyte ratio

Hrčak ID:

275338

URI

https://hrcak.srce.hr/275338

Publication date:

20.4.2022.

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