Original scientific paper
Serum ferritin concentration in solid tumor patients
Marija Skoko
; Department for Transfusion Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Irena Mihić-Lasan
; Department for Transfusion Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Jelena Culej
; Department for Transfusion Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Gorana Krajačić-Karas
; Department for Transfusion Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Tiha Vučemilo
; Department for Transfusion Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Deana Šturm
; Department for Transfusion Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Abstract
Ferritin is a positive acute phase reactant. It is produced and secreted by various cells such as hepatocytes, macrophages and cancer cells. This was a retrospective study which included 46 patients with solid tumors who were tested for ferritin level in plasma. The measured value of the ferritin concentration in plasma of patients was in the range from 5.98 to 850.78 μg/L, and the average measured value was 174.62 μg/L. For the control group, we also included 46 subjects. The measured value of ferritin in the control group was in the range from 5.94 to 351.54 μg/Ll, and the average measured value was 63.17 μg/L. There is a statistically significant difference between the two groups. Our data shows that the highest level of ferritin was measured in patient with breast cancer. By many studies done until now it is shown that iron metabolism is dysregulated in cancer, and that changes occur in both intracellular and extracellular ferritin.
Keywords
ferritin; cancer; H-subunit; iron
Hrčak ID:
275903
URI
Publication date:
25.11.2012.
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