Review article
Antitumor effect of bisphosphonates on osteosarcoma in some recent studies
Slaviša Belić
; Hospital Pharmacy, Clinical Hospital Dubrava, Zagreb, Croatia
Abstract
In medical treatment of osteoporosis, various metabolic bone diseases and bone resorption caused by metastatic tumors, bisphosphonates have a very significant role. Lately, the problem of their antitumor activity, especially in combination with antineoplastic drugs becomes a very important area of concern.
Studies define that bisphosphonates have effect on growth inhibition, adhesion and proliferation, invasiveness of tumor cell lines; they induce apoptosis, inhibitory effects on osteoclastic bone resorption, reduce secretion of the local growth factors that stimulate tumor growth and positively interact with antineoplastics in extermination of tumor cells.
Keywords
bisphosphonates; osteosarcoma; in vitro and in vivo studies; antitumor effect
Hrčak ID:
278790
URI
Publication date:
30.11.2009.
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