Original scientific paper
https://doi.org/10.3325/cmj.2022.63.141
Relationship between disease impact scores and C-reactive protein/albumin ratio in patients with psoriatic arthritis
Tugba Izci Duran
; Department of Internal Medicine, Division of Rheumatology, Ondokuz Mayıs University Medical Faculty, Samsun, Turkey
Melih Pamukcu
; Clinic of Rheumatology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Health Sciences University, Ankara, Turkey
Abstract
Aim To evaluate the relationships between the C-reactive
protein (CRP)/albumin ratio (CAR), neutrophil/lymphocyte
ratio (NLR), platelet/lymphocyte ratio (PLR), and Disease
Activity in Psoriatic Arthritis (DAPSA) and Psoriatic Arthritis
Impact of Disease 12-item-questionnaire (PsAID-12) scores
in patients with psoriatic arthritis (PsA).
Methods This cross-sectional study involved 160 (121 female) patients with PsA who were >18 years old and treated in the rheumatology clinic of Dışkapı Yıldırım Beyazıt
Education and Research Hospital between January 2020
and January 2021. Demographic and clinical data, PsAID12 and DAPSA scores, CRP, erythrocyte sedimentation rate
(ESR), albumin level, neutrophil, lymphocyte, and platelet
counts were recorded.
Results The mean age was 46.49±11.12 years; median
(min-max) disease duration was 2 years (0.5-34). The PsAID
score was ≥4 (high disease impact) in 74.4% of patients.
Patients with high disease impact had significantly higher CRP, ESR, CAR, NLR, PLR, neutrophil counts, and DAPSA
scores (P<0.001). PsAID scores significantly highly correlated with CRP (rho 0.864, P<0.001), DAPSA significantly
highly correlated with the CAR (rho 0.890, P<0.001). Receiver operating characteristic curve analysis showed
that the CAR (area under the curve [AUC] 0.901, P<0.05,
95% confidence interval [CI] 0.855-0.947, NLR (AUC 0.759,
P<0.05, 95% CI 0.680-0.838), and PLR (AUC 0.686, P<0.05,
95% CI 0.591-0.782) predicted high disease impact. The
cut-off value for the CAR was 0.98.
Conclusion The CAR can be useful in daily practice as a
simple and quick assessment method to evaluate disease
impact in PsA
Keywords
Hrčak ID:
279009
URI
Publication date:
21.4.2022.
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