Original scientific paper
https://doi.org/10.3325/cmj.2022.63.148
Risk factors for non-melanoma skin cancer development in renal transplant recipients: a 40 year retrospective study in Croatia
Nikolina Bašić-Jukić
; Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Tajana Borlinić
; Čakovec County Hospital, Čakovec, Croatia
Deša Tešanović
; Special Hospital Agram, Zagreb, Croatia
Ivica Mokos
; Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia
Ivan Krešimir Lukić
; Study of Nursing, Bjelovar University of Applied Sciences, Bjelovar, Croatia
Zrinka Bukvić Mokos
; Department of Dermatology and Venereology, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Abstract
Aim To determine the prevalence of non-melanoma skin
cancer (NMSC) and disease-specific risk factors in renal
transplant recipients (RTRs).
Methods This retrospective cohort study enrolled 1232
RTRs (736 men) treated in University Hospital Center Zagreb over 40 years. The effect of sex, age at transplantation, geographic residence, dialysis vintage, and the type
of immunosuppressive therapy on NMSC occurrence was
investigated.
Results The prevalence of NMSC was 6.81%. Overall,
60.7% of patients developed basal cell carcinoma (BCC)
and 30.9% of patients developed cutaneous squamous
cell carcinoma (cSCC). Only 8.3% developed both tumors.
The BCC:cSCC ratio was 1.76:1. The risk for NMSC was 50%
higher in men. Patients older than 50 years at transplantation were at greater risk for NMSC development. Residence
in an area with higher ultraviolaet radiation (UV) exposure
and dialysis vintage before transplantation did not influence NMSC development. Cyclosporine and azathioprine
treatment conferred a greater risk for NMSC than tacrolimus or mycophenolate mofetil treatment.
Conclusion RTRs are at high risk for NMSC development.
Sex, age at transplantation, and type of immunosuppressive therapy play a role in tumor development.
Keywords
Hrčak ID:
279010
URI
Publication date:
21.4.2022.
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