Original scientific paper
https://doi.org/10.26800/LV-144-supl3-3
Neurodegenerative changes caused by inhalation anesthetics
Nikola Lesar
; Zavod za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinika za tumore, Zagreb
Dyana Odeh
; Zavod za životinjsku fiziologiju, Prirodoslovno matematički fakultet Sveučilišta u Zagrebu
Dimitar Janev
; Zavod za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinika za tumore, Zagreb
Iva Korečić-Zrinjščak
; Zavod za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinika za tumore, Zagreb
Ana Žaja
; Zavod za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinika za tumore, Zagreb
Nada Oršolić
; Zavod za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinika za tumore, Zagreb
Gordana Brozović
; Zavod za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinika za tumore, Zagreb, Fakultet za dentalnu medicinu i zdravstvo, Sveučilište Josipa Juraja Strossmayera, Osijek
Supplements: 00d_SADRZAJ.pdf
Abstract
Main target of inhalation anesthetics is the brain. The sensitivity of the brain to oxidative stress is associated with its pronounced metabolic activity, production of ROS (reactive oxygen species), large number of mitochondria and reduced enzymatic antioxidant activity. Inhaled anesthetics, such as Isoflurane and Sevoflurane, increase the sensitivity of the brain to oxidative stress damage and increase the activity of beta-secretase (BACE), an enzyme that forms beta-amyloid plaques and causes beta-amyloid-dependent apoptosis of nerve cells. Furthermore, beta-amyloid plaques, pathological product of amyloid precursor protein (APP), represent an important feature for the development of neurodegenerative changes associated with the development of Alzheimer’s disease. By investigation of prooxidative, inflammatory and neurotoxic effects of inhaled anesthetics and analyzing the parameters of oxidative stress levels in brain tissue and pathohistological changes in rat brain related to neurodegenerative damage and inflammation, connection with long-term exposure to inhaled anesthetics disruption of oxidative/antioxidant homeostasis and formation of beta amyloid plaques can be made. By understanding the relationship between exposure to inhaled anesthetics and the occurrence of irreversible neurodegenerative changes it could be suggested to reduce using inhaled anesthetics to limit the neurodegenerative changes associated with the development of Alzheimer’s disease.
Keywords
SEVOFLURANE; ISOFLURANE; NEURODEGENERATIVE CHANGES; OXIDATIVE STRES
Hrčak ID:
284138
URI
Publication date:
25.9.2022.
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