Review article
https://doi.org/10.26332/seemedj.v6i2.246
Iron Chelation Therapy in COVID-19 Infection: A Review Article
Irena Krajina Kmoniček
orcid.org/0000-0002-0610-173X
; Department of Anesthesiology, Reanimatology and Intensive Medicine, Osijek University Hospital Centre, Osijek, Croatia
Anja Tomić
; Community Health Centre Vinkovci, Vinkovci, Croatia
Josip Kocur
orcid.org/0000-0002-5456-5870
; Department of Orthopedics and Traumatology, Osijek University Hospital Centre, Osijek, Croatia
Abstract
The recent outbreak of corona virus and coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus is a global concern. Despite efforts to clarify the physiology and potential therapy, specific guidelines for the treatment of COVID-19 disease have yet to be established, and many therapeutic options are under investigation. Accumulating evidence suggests that dysregulation of iron homeostasis contributes significantly to the pathogenesis of COVID-19 through its toxic effects by the formation of reactive oxygen species (ROS). This review focuses on summarizing the available literature and relevant studies conducted to date on the possible therapeutic effects of iron chelation therapy in the treatment of COVID-19 disease. Scientific databases (PubMed, Scopus, Google Scholar) were searched for relevant articles using the following keywords: COVID-19, SARS-CoV-2, coronavirus, clinical management, iron chelators/chelation. Research articles, reviews, research letters, case reports, and commentaries were considered. Although there is ample evidence of the potential beneficial effects of using iron chelators as adjuvant treatment in COVID-19, further research on this topic is needed.
Keywords
COVID-19; SARS-CoV-2; iron chelating agents; COVID-19 therapy
Hrčak ID:
286297
URI
Publication date:
28.11.2022.
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