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Safety : journal for the safety in the work organisation and living environment, Vol. 64 No. 4, 2022.

Review article

https://doi.org/10.31306/s.64.4.2

An update on permeation of protective medical gloves by antineoplastic drugs

Stefano Dugheri orcid id orcid.org/0000-0002-3078-7188 ; Careggi Univeristy Hospital, Industrial Hygiene and Toxicology Laboratory, Florence, Italy
Nicola Mucci ; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Enrico Mini ; University of Florence, Department of Health Science, Florence, Italy
Giovanni Cappelli orcid id orcid.org/0000-0002-5623-1671 ; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Elisabetta Bucaletti orcid id orcid.org/0000-0003-2060-5392 ; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Donato Squillaci orcid id orcid.org/0000-0001-8665-845X ; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Lucia Trevisani orcid id orcid.org/0000-0002-9245-0302 ; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy
Giulio Arcangeli ; University of Florence, Department of Experimental and Clinical Medicine, Florence, Italy

Full text: english pdf 273 Kb

page 341-357

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Abstract

Occupational exposure to antineoplastic drugs (ADs) handling and administration is one of the main risks in the healthcare sector. Dermal absorption represents the primary route of exposure to ADs. Personal preventive equipment, especially medical gloves, is crucial to safeguard the workers health in ADs handling; thus, chemicals permeating through protective materials is an essential aspect to estimate and consider. Several studies on permeation through medical gloves reported that breakthrough time and permeation rate are the values that must be studied, observing that physical-chemical properties of drugs, PPE materials and thickness, and temperature are crucial features to estimate them. In the European Union, standardized permeation testing is not mandatory for gloves used in ADs manipulation, in contrast with the United States, that proposed stringent requirements in the American Society of Testing and Materials International standard D6978-05. This review would help identify the main characteristics of the best protective glove used by employees frequently exposed to ADs: the major aspects implicated in permeation, reported in the literature, are listed and discussed.

Keywords

antineoplastic drugs, medical gloves, occupational monitoring, permeation testing, surface contamination, occupational health

Hrčak ID:

288494

URI

https://hrcak.srce.hr/288494

Publication date:

27.12.2022.

Article data in other languages: croatian

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