Review article

https://doi.org/10.24869/psyd.2022.390

NEUROPLASTICITY IN DEPRESSION: A NARRATIVE REVIEW WITH EVIDENCE-BASED INSIGHTS

Shiv Kumar Mudgal ; College of Nursing, All India Institute of Medical Sciences (AIIMS), Deoghar, Jharkhand, India
Santanu Nath ; Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), Deoghar, Jharkhand, India
Jitender Chaturvedi ; Department of Neurosurgery, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India
Suresh Kumar Sharma ; College of Nursing, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan, India
Jaydeep Joshi ; Huntercombe Manor Hospital, Maidenhead, United Kingdom

Abstract

Major Depressive Disorder (MDD) is one of the leading causes of disability worldwide. The current pharmacological treatment
options for MDD, which rely on the mono-amine hypothesis, has their limitations with respect to treatment non-response, partial
response etc. This propels for a search for a novel neurobiological understanding of MDD that can lead to novel treatment options.
A literature search strategy was thus employed using relevant keywords pertaining to the topic in PubMed, Embase and Google
Scholar. Systematic reviews and meta-analyses, narrative reviews and clinical trials were reviewed to incorporate the most robust
evidence-based literature available. A total of 37 publications were narrowed down based upon the topic. Alterations in brain
neuroplasticity, as evidenced by changes in neurotrophic factors and from neuroimaging, has been found to be a strong pathomechanism
for MDD. This link has been exploited to stimulate psychopharmacological research to treat MDD.

Keywords

neuroplasticity; depression; BDNF; antidepressant; ECT

Hrčak ID:

290232

URI

https://hrcak.srce.hr/290232

Publication date:

3.11.2022.

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