Original scientific paper

https://doi.org/10.24869/psyd.2022.431

INTERCONNECTION BETWEEN MIXED-HANDEDNESS, DIGIT RATIOS AND HAND AND FOOT MINOR ANOMALIES IN PREDICTING SCHIZOPHRENIA

Sinisa S. Babovic orcid.org/0000-0003-1912-193X ; Department of Anatomy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Biljana Dj. Srdic Galic orcid.org/0000-0001-7716-9072 ; Department of Anatomy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Bojana S. Krstonosic ; Department of Anatomy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Sonja D. Petricevic ; Department of Anatomy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Djendji S. Siladji ; Department of Psychiatry, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Sladjana Ralevic ; Department of Psychiatry, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Stefan M. Babic ; Department of Anatomy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Aleksa D. Novakovic ; Department of Anatomy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
Nebojsa P. Stilinovic orcid.org/0000-0003-0118-9418 ; Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

Abstract

Background: According to the neurodevelopmental theory, brain structuring early markers could be seen in different body parts
as minor physical anomalies. Alongside minor physical anomalies, handedness and index to ring finger ratio are brain development
indicators, specifically brain lateralization. Studies are consentient about the association of these findings with schizophrenia,
though there is inconsistency about individual anatomical regions' contribution. We proposed that handedness in combination with
morphological indicators of early brain development could be sensitive and specific in predicting schizophrenia status.
Subjects and methods: Within the list for the assessment of schizophrenia patients and normal controls of the Caucasian race
were seven categorical minor physical anomalies of hand and feet, handedness, and index to ring finger ratio. In this cross-sectional
study the examinees were recruited from January 2012 to December 2015.
Results: Forced-entry binary logistic regression model correctly classified 86.5% of patients and 99.2% of the comparison
subjects with a 92.8% overall accuracy. Mixed-handedness, hyperconvex fingernails, big gap between 1st and 2nd toe, and partial
syndactyly of 2nd and 3rd toe made a significant independent contribution to the patient-control prediction group status. Furthermore,
these items showed a significant correlation with the predictors of the head from the previous study.
Conclusion: Briefly, the limb components, assessed independently of other body regions, proved to be worthy as schizophrenia
predictors.

Keywords

neurodevelopmental markers; cerebral lateralization; atypical handedness; 2D:4D ratio

Hrčak ID:

290309

URI

https://hrcak.srce.hr/290309

Publication date:

3.11.2022.

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